Polygonic acid is the main active ingredient and is a SERT promoter and is therefore good for people with ADHD and will help them calm their mind, but is a stimulant for people with OCD and will make their ocd worse.

Unbelievable effects [1] including reduction of PGE2 and TNF-a

Treatment for snakebite venom [2]

Anti ulcer which is supposedly from pro PGE2 (and thus NMDA) effect and antioxidant [3] but my belief is it is a potent killer of h pylori. Turns out it is and effects a variety of molecular targets [4] high flavanoid extract from smartweed eliminated h pylori [5]

I suspect it might help the body break down amyloid plaque like alzheimers and insomnia. It does Contains Beta Sitosterol which fights alzheimers [6]

Contains Vitamin K

Polygonum hydropiper is folk remedy for the treatment of inflammation, headache, arthritis, epilepsy, colic pain, fever and infectious diseases insomnia, hypertension, angina helminthesis and kidney, disorders cerebral ischemia, stroke, parkingsons have been reported to exhibit anticholinesterase, antioxidant and gastroprotective activity neurodegenerative diseases and alzheimers [7]

Recently solvent extracts and essential oils from P. hydropiper have been reported to exhibit anticholinesterase, antioxidant, gastroprotective [8]

I suspect it may help with multiple sclerosis

Excellent against cough [9]

Host plant for japanese beetle edible beetle [10] that eats smartweed

How to use

Eating a leaf raw and fresh works and is probably way too much when you first start. A tiny young leaf is a good way to start


Smoking smartweed can be EXTREMELY DANGEROUS. But it also has the potential to be extremely beneficial and efficient if you use a teensy tiny dose. I mean like smoking a 1mm^2 piece of dried leaf. This is so small as to not even be really practical to dose. Basically a decent method is to make leaf powder and sprinkle a TINY amount of this on some tobacco to smoke.

Smoking too much seems to mess with serotonin in such a big way as to cause a serious rise in blood pressure, taking potassium may help to bring it down.

At reasonable doses you might feel like you got the "meat sweats" which I also notice with taking potassium phosphate (phosphorus). May also feel a slight pressure in the head and a little bit of clumsiness.

At higher doses one may feel the loss of time (which time perception seems to deal with dopamine and serotonin) [11] [12] [13] [14]. Basically what seems to be happening is you "space out" for moments and seem to loose that time, as in no memories were made during that time. So time seems to speed up relative to your thoughts. This is by reducing serotonin, it increases the relative (but not actual) abundance of Dopamine, basically increases the dopamine/serotonin ratio and therefore makes time feel faster.


Polygonic acid and many more [15]

Antioxidant and Anti-inflammatory

Stronger than ascorbic acid [16]

Stronger anti-inflammatory than asprin [17] or salicin, of which salicin helped me most with insomnia besides smartweed. Smartweed significantly reduces PGE2 which is likely the mechanism of action in insomnia treatment.


Staphylococcus s aureus, Pasteurella multocida, Streptococcus, Salmonella, Escherichia e coli, bacillus, pseudomonas [18]

Works for ulcer epilepsy cholera and hemorrhoids[19]

Immune and metabolic factors

Increases IgG, IgA, and decreases TNF-a, IL-1, IL-4, IL-6 [20]

For liver health reduces ALT, AST, TBA, TBIL, LDH in serum, increase activity of natural antioxidants SOD and GSH in liver, reduce the content of lipid peroxide MDA inactivate Hsp90 in hepatocytes, and improve spleen protection of the liver, reduced fibrosis via TGF-b [21]


reduce structural damage of cardiomyocytes and glomeruli kidney [22]


reduce structural damage of cardiomyocytes and glomeruli kidneys [23]


Effective against various types of cancer [24] I would guess because of it's effect on pasteurella and/or h pylori or listeria


Hypochondriac [25]

I suspect that pasteurella causes serotonin overregulation and thus insomnia [26] and smartweed sesquiterpenoid blocks serotonin with a halflife of just a couple hours causing sleepiness. Yes pasteurella increases serotonin [27] probably via 5-HTP [28]

Sesquiterpenoids, of which smartweed has polygonic acid and others, can either enhance or block SERT serotonin transporter depending on whether it is aristolane or nardosinane like [29]. Comparing structures polygonic acid [30] looks more nardosinane [31] and not aristolane [32] which means it activates SERT which means it reduces excess serotonin. So ya this is probably how smartweed helps treat insomnia. Enhancing SERT like smartweed does, is basically the opposite of the toxic SSRIs.

Sesquiterpenoids may also hold the anti-alzheimers effects [33]


Serotonin effects blood pressure and high blood pressure [34]

SERT promoters like smartweed may cause blood clots by increasing platelet uptake of 5-HT [35] [36] as well as heart attack, stroke, asthma, and sepsis.


Good for horses [37]

If it indeed is effective against pasteurella then it is likely good for all animals especially rabbits, unless it is toxic to any specific species.

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