PGE 2

Causes wakefulness and decreasing of slow wave sleep and paradoxical sleep [1].

Intricately linked to chronic fatigue, insomnia, and intracellular bacteria infections of the monocytes. Also linked to iron overload and GLA.

PGE2 linked to calcium, iron, and NMDA [2]

PGE2 seems to elevate NMDA or perhaps vice versa [3].

Upregulated in Rickettsia intracellular bacteria [4]

Reduces cellular immunity [5].

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