PGE 2

Linked to COX2 Causes wakefulness and decreasing of slow wave sleep and paradoxical sleep [1].

Causes migraines [2].

Intricately linked to chronic fatigue, insomnia, and intracellular bacteria infections of the monocytes. Also linked to iron overload and GLA. One way it can cause iron overload hemochromatosis is by inducing the stomach to produce excess acid [3].

PGE2 linked to calcium, iron, and NMDA [4]

Iron chelators enhance PGE2 probably by making the iron more active to participate in Fenton reactions [5].

PGE2 seems to elevate NMDA or perhaps vice versa [6].

Upregulated in Rickettsia intracellular bacteria [7]

Reduces cellular immunity [8].

PGE2 upregupated in mercury exposure [9] [10]

Stimulated by legume exposure and high iron [11].

PGE2 increased in strongyloides infection [12].

PGE2 increased by h pylori [13].

Hepcidin can be upregulated by the same things that upregulate pge2 [14]. This might cause the body to shut off the HFE gene in hemochromatosis.

Causes of upregulation

Chronic Hepatitis B infection [15].

Strongyloides infection [16] or other worms [17].

Effects

Stimulates aromatase which converts testosterone to estrogen causing gynecomastia [18].

Activates histamine system [19].

PGE2 allows for breathing [20] so too powerful an inhibitor could cause respiratory collapse and SIDS. Also too much PGE2 can have a similar effect by fatiguing the astrocytes.

Treatments

Bisibilol and ginger reduced pge2 [21]. Echinacea possibly as well [22].

Mentha Longifolia (and maybe peppermint) reduced pge2 and COX2 [23].

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