COX 2

COX2 leads to the production of prostaglandins such as PGE2 and PGD2 from GLA and other fatty acids.

Levels

See also PGE2

Heavy metals

Mercury increases it and cyanide decreases it. Arsenite (arsenic) increases it [1]. Lead increases it [2].

Herbs

Sulforaphane decreases it [3].

Nicotine from tobacco strongly induces (increases) it.

THC?

Homocysteine

Increases cox2 [4]

Disease

COX2 upregulation seen in chronic fatigue [5].

Reduce immunity to intracellular bacteria [6]

Involvement in cancer [7].

Cox2 upregulation enhances TH2 immunity via PGE2 against strongyloides [8]

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