Intracellular Bacteria

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Intracellular bacteria tend to feed off iron in macrophages. Iron in macrophages is elevated in high hepcidin conditions.

Common species

Listeria, salmonella, chlamydia, brucella, mycobacteria, Rickettsia. Brucella is especially known to raise hepcidin which might be the cause of the hemochromatosis gene mutation.

Symptoms

Intracellular bacteria are implicated in chronic fatigue, cystic fibrosis and other issues [1].

Link to rheumatic disease [2]

Vitamin D and symptoms [3] rheumatoid arthritis, fibromyalgia, sarcoidosis.

Linked to multiple sclerosis, alzheimers, and parkingsons [4].

PGE2

Rickettsia bacteria upregulate PGE2 [5]

Cellular immunity

sequestering iron, oxidation, nitric oxide, acidification, restrict fatty acids, restrict amino acids, antimicrobial peptides and cytokines [6].

CD4 and CD8 responses [7]

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