Homocysteine
See also Homocysteine treatment and pernicious anemia
Reduces collagen crosslinking [1]. Which probably leaves people more suseptible to intracellular bacteria
May be linked to hepcidin in causing iron overload, it increases hepcidin [2] but of course the body might genetically downregulate hepcidin to compensate causing hemochromatosis
Causes mood swings maybe heartburn [3]
Lowered by folic acid.
Lowered by Zinc in a non-folic acid way [4]
Causes strokes
Iron overload causes homocysteine production [8] [9]
Associated with high blood pressure hypertension and obesity [11]
Might be associated with bipolar
Testosterone reduces it [12]
Also causes miscarriage and heart attack and blocks dopamine receptor [13]
Causes excitotoxicity via activation of NMDA receptor [14]
Also causes diabetes and rheumatoid arthritis and alzheimers[15]
Induces oxidative stress [17]
Iodine increases homocysteine [18]
Homocysteine increases severity of infection of covid-19 and probably predicts bad reactions to vaccine [19]
Causes depression, dementia, and anger and violence [23].
B6 and B9 but not B12 lower homocysteine [24]
Elevated homocysteine symptoms
- Oxidative stress [25]
- Possibly sleep apnea [26]
- Chronic fatigue and fibromyalgia [27]
- Multiple sclerosis [28]
- Feelings of stress and anxiety [29]
- Suicide depression alexithymia [30] and maybe bipolar
- Very likely heartburn and scrotal itch
- Anemia [31]
- High cholesterol [32] [33]
Things that raise homocysteine
- Niacinamide [34] and symptoms like insomnia etc that implies homocysteine [35]
- Methionine
- Exercise [36]
- Stress [37]
- Heavy metals including cadmium, mercury, lead, arsenic et. [38]. With mercury things can be reversed so they might need methylation support in the form of methyl B12 in addition to the folate. Folate increases lead excretion [39] so it is probably a chelator of other heavy metals too [40] like cadmium [41] and mercury [42] and urinary excretion of arsenic via folate mediated methylation of the arsenic [43] removing the root cause of many diseases.
Things that correspond to reduction of homocysteine
- Folic acid [44]
- Cobalamin [45] necessary for folic acid [46]
- Haemoglobin [47]
- Pyridoxine
- Riboflavin [48] [49] necessary for pyridoxine [50] and folic acid [51]
- Zinc
- Trimethylglycine [52] aka betaine [53]
- Taurine [54] [55]
- Choline [56]
- Creatine [57]
- Magnesium [58]
- Thiamine [59] necessary for folic acid.
- Calcium [60]
- Serine [61]
- Selenium [62]
- Other natural methods [63]
- Bieng in shape [64] but stress including exercise can raise it.
- Vitamin D as a way to lower lead in the body [65] which lead raises homocysteine. Also folic acid chelates other heavy metals as seen in the things that raise homocysteine section
Metabolism
Either cobalamin and mehylated folic acid process or serine and pyridoxine required [66]
Elevated homocysteine is correlated with elevated histamine at least in depression patients [67]. If elevated homocysteine causes elevated histamine then lowering homocysteine via folic acid then you would expect folic acid to lower heartburn which is from elevated gut histamine. I have noticed this effect. The mechanism may be that homocysteine inhibits diamine oxide (DAO) [68], and DAO lowers histamine production from dietary histidine. So folic acid lowers homocysteine which increases DAO.
Zinc is an essential part of the folic acid pathway [69]
E coli produces homocystiene when fed acetic acid [70]
CSF homocysteine
Csf homocysteine elevated but not blood in chronic fatigue and fibromyalgia [71]
Sleep
Sleep duration either increased from normal or decreased (insomnia or hypersomnia) in cases of high homocysteine. Low homocysteine causes 7 hr sleep duration [72].
Other pages that link to Homocysteine:
- L
Attachments to Homocysteine:
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