See also Homocysteine treatment and pernicious anemia

Reduces collagen crosslinking [1]. Which probably leaves people more suseptible to intracellular bacteria

May be linked to hepcidin in causing iron overload, it increases hepcidin [2] but of course the body might genetically downregulate hepcidin to compensate causing hemochromatosis

Causes mood swings maybe heartburn [3]

Lowered by folic acid.

Lowered by Zinc in a non-folic acid way [4]

Induces COX2 [5] and PGE2 [6]

May cause insomnia [7]

Causes strokes

Iron overload causes homocysteine production [8] [9]

Associated with PCOS [10]

Associated with high blood pressure hypertension and obesity [11]

Might be associated with bipolar

Testosterone reduces it [12]

Also causes miscarriage and heart attack and blocks dopamine receptor [13]

Causes excitotoxicity via activation of NMDA receptor [14]

Also causes diabetes and rheumatoid arthritis and alzheimers[15]

Coffee increases it [16]

Induces oxidative stress [17]

Iodine increases homocysteine [18]

Homocysteine increases severity of infection of covid-19 and probably predicts bad reactions to vaccine [19]

Causes migraine [20]

Causes cataract [21]

Factor in epilepsy [22]

Causes depression, dementia, and anger and violence [23].

B6 and B9 but not B12 lower homocysteine [24]

Elevated homocysteine symptoms

Things that raise homocysteine

Things that correspond to reduction of homocysteine


Either cobalamin and mehylated folic acid process or serine and pyridoxine required [66]

Elevated homocysteine is correlated with elevated histamine at least in depression patients [67]. If elevated homocysteine causes elevated histamine then lowering homocysteine via folic acid then you would expect folic acid to lower heartburn which is from elevated gut histamine. I have noticed this effect. The mechanism may be that homocysteine inhibits diamine oxide (DAO) [68], and DAO lowers histamine production from dietary histidine. So folic acid lowers homocysteine which increases DAO.

Zinc is an essential part of the folic acid pathway [69]

E coli produces homocystiene when fed acetic acid [70]

CSF homocysteine

Csf homocysteine elevated but not blood in chronic fatigue and fibromyalgia [71]


Sleep duration either increased from normal or decreased (insomnia or hypersomnia) in cases of high homocysteine. Low homocysteine causes 7 hr sleep duration [72].

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