Hemochromatosis

See also: iron overload

It is probably a runaway cycle of PGE2 elevation which causes reduced hepcidin and also gynecomastia from enhanced aromatase [1].

HFE C282Y

This gene mutation arose about 6,000 years ago in northern latitutes and wet environments [2]. Part of this reason could be drinking water from shallow wells that was infected with iron bacteria including potentially Pseudomonas and/or siderophilic bacteria that live on the released iron.

Can be caused by immune reactivity to hepcidin or at least low pro-hepcidin (precursor)[3]

HFE, the gene that is knocked out in hemochromatosis, stimulates hepcidin production. [4] So using an herb that stimulates hepcidin might be a great treatment.

When hepcidin is down in this disease, ferroportin is unchanged in hepatocytes in the liver leading to iron accumulation there but ferroportin is increased in macrophages leading to a iron deficiency in them. [5] what this means is when macrophages are low on iron they produce less il-6 and tnf-a and more pge2 and in some cases or perhaps parts of the body like the scalp in baldness? pgd2.

Doxycycline seems to induce ferroportin expression which might be linked to fatal familial insomnia which is thought to be due to prions. [6] but it seemsthat it is just doxycycline inducible ferroportin overexpressers [7] but who knows if any humans contain doxycycline inducible transgenes.

Benefits for the mutation

Intracellular bacteria like salmonella, chlamydia, ajd mycobacterium are inhibited since elevated ferroportin makes macrophages have less iron [8]. Also Listeria and Brucella the latter strongly promotes hepcidin [9] which could be a huge reason for the body to delete the gene.

Ferroportin

Aside from hepcidin ferroportin recepton can also be a cause [10]

Deficiency causes

Ascorbic acid deficiency Scurvy linked to hemochromatosis [11] they think it is an effect of high iron, I think it may be a cause of the body not able to excrete iron without adequate vitamin c.

Bacterial causes

Chlamydia due to mismaking of heme for porphyrins [12] [13].

Microbes known to rely on excess iron [14]

These microbes have an evolutionary motive to cause hemochromatosis, iron overload, Thalassemia, orhemolysis potentially

Fungi: Candida, Cryptococcus, Histoplasma, Paracoccidioides, Rhizopus, Trichosporon, Aspergillus, Pneumocystis

Protozoa: Entamoeba, Leishmania, Naegleria, Plasmodium, Toxoplasma, Trypanosoma

Gram-positive and acid-fast bacteria: Bacillus, clostridia, corynebacteria, Erysipelothrix, Listeria, mycobacteria, staphylococci, streptococci, Gemella

Gram-negative bacteria: Acinetobacter, Aeromonas, Alcaligenes, Capnocytophaga, Campylobacter, Chlamydia, Ehrlichia, Enterobacter, Escherichia, Klebsiella, Legionella, Moraxella, Neisseria, Pasteurella, Proteus, Pseudomonas, Plesiomonas, Shigella, Vibrio, Yersinia

Viruses: Hepatitis B and C, cytomegalovirus, parvovirus, HIV

Treatments

See iron overload

quercetin okra EGCG rutin tea taurine [15]

Nutrition therapy and also enhanced suseptibility to lead poisoning [16] maybe also mercury? Folic acid treats both [17]

Ferric citrate is chelated with phosphorus [18] so in iron overload phosphorus is probably depleted. Also I'm interested whether citrate or ascorbate helps the chelation process.

Sufferers are coq10 deficient [19]

Links

Overview of hemochromatosis including chronic fatigue and arthritis as most common symptoms [20]

Retinoids low in hemochromatosis [21].

Tests you can get [22].

Used to be treated with phosphate salts [23]

Phosphorus and calcium in iron excretion in hemachromatosis [24]

Other pages that link to Hemochromatosis:

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Attachments to Hemochromatosis:

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